An efficient nanoreactor reverses the tumor immunosuppressive microenvironment through synergetic dual-route reactions.

Tumors being immunologically cold is the main reason for the unsatisfactory clinical performance of cancer immunotherapy. An efficient nanoreactor was developed to reverse the tumor immunosuppressive microenvironment. This nanoreactor can effectively convert intracellular glucose and GSH into ROS and H2S in tumors for enhanced chemodynamic therapy and complete energy metabolism block through synergistic dual-route reactions, consequently leading to efficient immunogenic cell death and eliciting a robust immune response.