Phytomedicine : international journal of phytotherapy and phytopharmacology · 2026
Phytochemistry, pharmacology, toxicology, and applications of the genus Dendrobium: An updated review from bioactive constituents and mechanisms to translational perspectives.
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
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Zhao Hongying, Shang Mingyue, Zhu Zemei, Wang Yaping, Zeng Yifan, Xu Juan, Hu Yingying, Li Xinping, Duan Baozhong
Аннотация
BACKGROUND: The genus Dendrobium, the second largest within Orchidaceae, is widely used in traditional medicine and shows significant promise for disease prevention and management. Nevertheless, current research remains fragmented. A systematic understanding of its phytochemical profile, bioactivities, toxicology, and applications is limited, hindering the translational development and utilization of Dendrobium resources.
PURPOSE: This review aims to synthesize recent advances in phytochemistry, bioactivities, toxicology, and the potential application of the genus Dendrobium, thereby providing a scientific basis for drug discovery and the sustainable use of Dendrobium resources.
METHODS: A systematic literature search was conducted across PubMed, Web of Science, Baidu Scholar, Google Scholar, and CNKI. Keywords included "Dendrobium" combined with "chemical compounds," "pharmacology," "toxicology," or "application". Literature screening and data extraction followed established systematic review principles.
RESULTS: To date, 549 phytochemicals (including 99 new compounds) have been systematically summarized in Dendrobium spp.. Moreover, Dendrobium spp. are rich in amino acids, fatty acids, vitamins, and essential minerals. These constituents exhibit diverse pharmacological activities, including immunomodulatory, prebiotic, antioxidant, anti-aging, anticancer, anti-inflammatory, anti-diabetic, hepatoprotective, and neuroprotective effects. These properties underpin expanding applications in pharmaceuticals, functional foods, active packaging, cosmetics, hydrogels, and nanomaterials.
CONCLUSION: The genus Dendrobium is an important medicinal resource in traditional medicine with substantial potential for therapeutic and functional applications. Future research should prioritize elucidating the relationships between specific chemical constituents and the pharmacological activities, as well as clarifying the underlying mechanisms of action. This will facilitate the development of Dendrobium-derived preventive healthcare products and promote clinical translation.
PURPOSE: This review aims to synthesize recent advances in phytochemistry, bioactivities, toxicology, and the potential application of the genus Dendrobium, thereby providing a scientific basis for drug discovery and the sustainable use of Dendrobium resources.
METHODS: A systematic literature search was conducted across PubMed, Web of Science, Baidu Scholar, Google Scholar, and CNKI. Keywords included "Dendrobium" combined with "chemical compounds," "pharmacology," "toxicology," or "application". Literature screening and data extraction followed established systematic review principles.
RESULTS: To date, 549 phytochemicals (including 99 new compounds) have been systematically summarized in Dendrobium spp.. Moreover, Dendrobium spp. are rich in amino acids, fatty acids, vitamins, and essential minerals. These constituents exhibit diverse pharmacological activities, including immunomodulatory, prebiotic, antioxidant, anti-aging, anticancer, anti-inflammatory, anti-diabetic, hepatoprotective, and neuroprotective effects. These properties underpin expanding applications in pharmaceuticals, functional foods, active packaging, cosmetics, hydrogels, and nanomaterials.
CONCLUSION: The genus Dendrobium is an important medicinal resource in traditional medicine with substantial potential for therapeutic and functional applications. Future research should prioritize elucidating the relationships between specific chemical constituents and the pharmacological activities, as well as clarifying the underlying mechanisms of action. This will facilitate the development of Dendrobium-derived preventive healthcare products and promote clinical translation.