Experimental study on anaphylaxis of qingkailing injection and its components on Beagle dogs.

OBJECTIVE

To study the anaphylaxis of Qingkailing injection (QI) and its components.

METHODS

Experimental anaphylactoid and allergic reactions were used. Changes in the behaviors of Beagles and serum levels of histamine, immunoglobulin (Ig)E, IgG, IgM, eosinophil cationic protein (ECP), and interleukin (IL)-4, as well as blood pressure, after injecting QI and its components on the forelimb veins of Beagles were observed.

RESULTS

According to comprehensive determination of abnormal behavior scores and changes in serum levels of histamine, IgE, IgG, IgM, ECP, and IL-4, as well as in blood pressure, radix isatidis and hyodeoxycholic acid caused anaphylactoid reactions, and honeysuckle, radix isatidis, hydrolysate, cholic acid and Gardenia jasminoides caused allergic reactions. The anaphylaxis of QI involved anaphylactoid and allergic reactions.

CONCLUSION

QI and its components need to be refined further to improve the safety, efficacy, and quality of its use in clinical settings.