European journal of haematology · 2026
Platelet Counts During Pregnancy as Predictor of Subsequent Myeloproliferative Neoplasm.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Klok Freja Rueholm, Jørgensen Katrine Jeong, Larsen Morten Kranker, Dahl Morten, Jørgensen Finn Stener, Skov Vibe, Kjær Lasse, Ellervik Christina, Jørgensen Henrik Løvendahl, Hasselbalch Hans Carl
Аннотация
OBJECTIVES: Myeloproliferative neoplasms (MPNs) are associated with increased thrombosis risk, and earlier identification is essential to reduce preventable complications. We investigated whether platelet counts during pregnancy were higher in women diagnosed with MPN after pregnancy than in controls.
METHODS: We conducted a nested case-control study of pregnant women in two Danish regions between 2010 and 2017 using registry and laboratory data. The primary exposure was platelet counts during pregnancy, and the primary outcome was a subsequent MPN diagnosis.
RESULTS: We included 49 cases with subsequent MPN, and 979 matched controls. Cases had significantly higher platelet counts (×109/L) during pregnancy (325 (IQR 199-419) vs. 219 (IQR 183-254), p = 0.002), and platelet counts > 400 occurred in 29% of cases versus 2% of controls (p < 0.001). Adjusted models showed an estimated 85 higher platelet count in cases, and platelet counts > 400 during pregnancy were associated with an 18-fold increased odds ratio (95% CI: 6-61) for later MPN. MPN status was strongly associated with higher platelet counts before, during, and after pregnancy.
CONCLUSION: Elevated platelet counts during pregnancy are strongly associated with subsequent MPN, suggesting that routine prenatal platelet counts may enable early identification of women at risk of MPN.
METHODS: We conducted a nested case-control study of pregnant women in two Danish regions between 2010 and 2017 using registry and laboratory data. The primary exposure was platelet counts during pregnancy, and the primary outcome was a subsequent MPN diagnosis.
RESULTS: We included 49 cases with subsequent MPN, and 979 matched controls. Cases had significantly higher platelet counts (×109/L) during pregnancy (325 (IQR 199-419) vs. 219 (IQR 183-254), p = 0.002), and platelet counts > 400 occurred in 29% of cases versus 2% of controls (p < 0.001). Adjusted models showed an estimated 85 higher platelet count in cases, and platelet counts > 400 during pregnancy were associated with an 18-fold increased odds ratio (95% CI: 6-61) for later MPN. MPN status was strongly associated with higher platelet counts before, during, and after pregnancy.
CONCLUSION: Elevated platelet counts during pregnancy are strongly associated with subsequent MPN, suggesting that routine prenatal platelet counts may enable early identification of women at risk of MPN.