Enhancement of the Antioxidant Activity of Hedysari Radix Particle Dispersion via ZIF-8/PEG Surface Co-Adsorption.

Herein, a co-adsorption modification based on ZIF-8 was introduced with the contribution of polyethylene glycol package to enhance the antioxidant potency of the Hedysari Radix disperse particles. In the solution system containing ethanol, the rough surface of the original Hedysari Radix disperse particles was improved by the typical co-adsorption modification with ZIF-8 and further smoothed by the package. The co-adsorption modifications, including ZIF-8 only, polyethylene glycol only, and ZIF-8 with polyethylene glycol, were all studied in the solution system. In particular, the modification that combined both the polyethylene glycol package and a suitable amount of ZIF-8 achieved the most significant enhancement of the catalase activity as well as the total antioxidant capacity value. The obtained hit platform alleviated the oxidative stress upon Caenorhabditis elegans and extended the survival time. This work suggested that meaningful co-adsorption modification could improve the potency of medicinal plant resources.