EJHaem · 2026
Somatic Mitochondrial-Nuclear DNA Transfer in Lymphoproliferative Disorders.
СтатьяНазвание и аннотация: Перевод в очереди
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Stewart James Peter, Darzentas Nikos, Alcoceba Miguel, Sarasquete Maria Eugenia, Moorman Anthony V, Catherwood Mark, Regmi Binaya, Pott Christiane, Langerak Anton W, Gonzalez David
Аннотация
INTRODUCTION: Somatic mitochondrial-nuclear DNA transfer (SMNT) is a process by which mitochondrial DNA (mtDNA), of varying sizes, integrate into the nuclear genome and has been previously reported in solid tumours.
METHODS: EuroClonality-NGS DNA Capture sequencing data from 755 lymphoid malignancies and 59 lymphoid cell lines were analysed for SMNT-associated structural variants.
RESULTS: Five malignancies (0.66%) harboured SMNTs, predominantly involving IGH genes, with one PTEN gene disruption identified. Breakpoint features supported non-homologous end joining-mediated integration.
CONCLUSION: SMNTs are rare but recurrent events in lymphoid malignancies and may represent stable clonal markers for minimal residual disease monitoring.
TRIAL REGISTRATION: The authors have confirmed clinical trial registration is not needed for this submission.
METHODS: EuroClonality-NGS DNA Capture sequencing data from 755 lymphoid malignancies and 59 lymphoid cell lines were analysed for SMNT-associated structural variants.
RESULTS: Five malignancies (0.66%) harboured SMNTs, predominantly involving IGH genes, with one PTEN gene disruption identified. Breakpoint features supported non-homologous end joining-mediated integration.
CONCLUSION: SMNTs are rare but recurrent events in lymphoid malignancies and may represent stable clonal markers for minimal residual disease monitoring.
TRIAL REGISTRATION: The authors have confirmed clinical trial registration is not needed for this submission.