Uptake of PSMA-ligands in normal tissues is dependent on tumor load in patients with prostate cancer.

BACKGROUND

Preterm births represent approximately 10% of all births in the United States (US) annually. Although North Dakota (ND) has large rural and American Indian populations that experience disparities in health outcomes relative to the general population, few studies have investigated risk factors of preterm births in this state. Therefore, the objective of this study was to investigate predictors of preterm births in ND among women who had a live singleton birth and no prior history of preterm births.

METHODS

Data on live births from 2017 to 2021 were obtained from the ND Pregnancy Risk Assessment Monitoring System. Potential predictors of preterm birth were identified using a conceptual model. Multivariable logistic regression was then used to investigate and identify significant predictors of preterm births.

RESULTS

The overall prevalence of preterm birth in North Dakota from 2017 to 2021 was 8.1%. However, among the population of interest in this study, which excluded births with multiple infants as well as women with a prior history of preterm birth, the preterm birth rate was 6.4%. Race, age, pregestational diabetes, and gestational hypertension were significantly associated with preterm birth in the final multivariable logistic model. The odds of preterm birth were higher among women who were American Indian (adjusted odds ratio (AOR) = 1.7, 95% confidence interval (CI) [1.3-2.4]), were aged 35 years or older (AOR = 1.6, 95% CI [1.01-2.5]), had pregestational diabetes (AOR = 4.3, 95% CI [2.0-9.3]), and had gestational hypertension (AOR = 4.5, 95% CI [3.1-6.7]) compared to women who were White, aged 20-34 years, and did not have pregestational diabetes or gestational hypertension.

CONCLUSIONS

Preventing and controlling chronic diabetes and hypertensive disorders of pregnancy is critical for reducing the risk of preterm birth, especially among women of advanced maternal age. Further research is needed to understand the underlying causes of racial disparities of preterm birth in ND.