Enhanced bactericidal activity of selenosteroid complexes with zinc, copper, and cobalt against resistant bacterial strains.

Let's enhance the activity of selenosteroids! For this purpose, we have obtained a new class of metal complexes with the steroid β-hydroxy-phenylselenide as a model ligand using a simple and efficient methodology. The obtained compounds were characterised by 1H and 77Se nuclear magnetic resonance spectroscopy, infra-red spectroscopy, mass spectra, X-ray diffraction and thermogravimetric analysis. The bactericidal activity of the complexes against Pseudomonas aeruginosa and Staphylococcus aureus was then evaluated using a standard killing assay. The results showed that the copper and cobalt complexes with selenosteroid exhibited significant bactericidal activity against P. aeruginosa. The presented synthetic method shows potential for obtaining compounds that may be effective in treating infections caused by these clinically relevant bacterial strains.