Mediators of inflammation · 2014
Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Ribeiro Edlene Lima, Barbosa Karla Patricia de Souza, Fragoso Ingrid Tavares, Donato Mariana Aragão Matos, Gomes Fabiana Oliveira dos Santos, da Silva Bruna Santos, Soares e Silva Amanda Karolina, Rocha Sura Wanessa Santos, da Silva Junior Valdemiro Amaro, Peixoto Christina Alves
Аннотация
Diethylcarbamazine (DEC) is an antifilarial drug with potent anti-inflammatory properties as a result of its interference with the metabolism of arachidonic acid. The aim of the present study was to evaluate the anti-inflammatory activity of DEC in a mouse model of acute inflammation (carrageenan-induced pleurisy). The injection of carrageenan into the pleural cavity induced the accumulation of fluid containing a large number of polymorphonuclear cells (PMNs) as well as infiltration of PMNs in lung tissues and increased production of nitrite and tumor necrosis factor-α and increased expression of interleukin-1β, cyclooxygenase (COX-2), and inducible nitric oxide synthase. Carrageenan also induced the expression of nuclear factor-κB. The oral administration of DEC (50 mg/Kg) three days prior to the carrageenan challenge led to a significant reduction in all inflammation markers. The present findings demonstrate that DEC is a potential drug for the treatment of acute lung inflammation.