CNS neuroscience & therapeutics · 2024
Role of dendritic cells in spinal cord injury.
СтатьяОбзорПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Han Xiaonan, Zhang Mingkang, Yan Liyan, Fu Yikun, Kou Hongwei, Shang Chunfeng, Wang Junmin, Liu Hongjian, Jiang Chao, Wang Jian, Cheng Tian
Аннотация
BACKGROUND: Inflammation can worsen spinal cord injury (SCI), with dendritic cells (DCs) playing a crucial role in the inflammatory response. They mediate T lymphocyte differentiation, activate microglia, and release cytokines like NT-3. Moreover, DCs can promote neural stem cell survival and guide them toward neuron differentiation, positively impacting SCI outcomes.
OBJECTIVE: This review aims to summarize the role of DCs in SCI-related inflammation and identify potential therapeutic targets for treating SCI.
METHODS: Literature in PubMed and Web of Science was reviewed using critical terms related to DCs and SCI.
RESULTS: The study indicates that DCs can activate microglia and astrocytes, promote T-cell differentiation, increase neurotrophin release at the injury site, and subsequently reduce secondary brain injury and enhance functional recovery in the spinal cord.
CONCLUSIONS: This review highlights the repair mechanisms of DCs and their potential therapeutic potential for SCI.
OBJECTIVE: This review aims to summarize the role of DCs in SCI-related inflammation and identify potential therapeutic targets for treating SCI.
METHODS: Literature in PubMed and Web of Science was reviewed using critical terms related to DCs and SCI.
RESULTS: The study indicates that DCs can activate microglia and astrocytes, promote T-cell differentiation, increase neurotrophin release at the injury site, and subsequently reduce secondary brain injury and enhance functional recovery in the spinal cord.
CONCLUSIONS: This review highlights the repair mechanisms of DCs and their potential therapeutic potential for SCI.