Modern rheumatology · 2011
A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details.
СтатьяПоддержка исследования: вне правительства СШАОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Umehara Hisanori, Okazaki Kazuichi, Masaki Yasufumi, Kawano Mitsuhiro, Yamamoto Motohisa, Saeki Takako, Matsui Shoko, Sumida Takayuki, Mimori Tsuneyo, Tanaka Yoshiya, Tsubota Kazuo, Yoshino Tadashi, Kawa Shigeyuki, Suzuki Ritsuro, Takegami Tsutomu, Tomosugi Naohisa, Kurose Nozomu, Ishigaki Yasuhito, Azumi Atsushi, Kojima Masaru, Nakamura Shigeo, Inoue Dai, Research Program for Intractable Disease by Ministry of Health, Labor and Welfare (MHLW) Japan G4 team
Аннотация
IgG4-related disease (IgG4RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. IgG4RD may be present in a certain proportion of patients with a wide variety of diseases, including Mikulicz's disease, autoimmune pancreatitis, hypophysitis, Riedel thyroiditis, interstitial pneumonitis, interstitial nephritis, prostatitis, lymphadenopathy, retroperitoneal fibrosis, inflammatory aortic aneurysm, and inflammatory pseudotumor. Although IgG4RD forms a distinct, clinically independent disease category and is attracting strong attention as a new clinical entity, many questions and problems still remain to be elucidated, including its pathogenesis, the establishment of diagnostic criteria, and the role of IgG4. Here we describe the concept of IgG4RD and up-to-date information on this emerging disease entity.