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DOI 10.3390/cancers18172739

Медицинская библиотека · Cancers · 2026

Perioperative Outcomes and Learning Curve for Robotic Liver Resection: An Exploratory Single-Surgeon CUSUM Analysis Stratified by IWATE Difficulty Score.

Vella Roberta, Bici Kejd, Li Petri Sergio, Pagano Duilio, Bonsignore Pasquale, Tropea Alessandro, Calamia Sergio, Accardo Caterina, Vella Ivan, Vitale Irene, Chimenti Federica, Barbara Marco, di Francesco Fabrizio, Gruttadauria Salvatore

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Аннотация

Background

Robotic liver resections (RLRs) are rapidly expanding, yet the association between the learning curve, procedural complexity, and outcomes at intermediate-volume centers remains poorly defined. We evaluated the learning-curve trajectory and perioperative outcomes of a single surgeon's initial RLR experience according to procedural complexity (IWATE difficulty score).

Methods

We retrospectively analyzed 58 consecutive RLRs at an intermediate-volume center. We stratified outcomes by IWATE difficulty category and chronological tertile (early/middle/late). Textbook outcomes (TOs) and a composite failure endpoint (conversion, major complications [Clavien-Dindo ≥ IIIa] and 90-day mortality) were also assessed. Learning-curve behavior was examined with CUSUM and risk-adjusted CUSUM (RA-CUSUM) analyses.

Results

Fifty-four procedures (93.1%) were minor resections and four were major hepatectomies; two were classified as IWATE Expert difficulty. Median estimated blood loss was 100 mL; conversion occurred in 10.3%, overall morbidity in 10.3% and severe complications (Clavien-Dindo ≥ IIIa) in 3.4%, with no mortalities within 90 days. TOs were achieved in 69.0% using the Delphi (TOLS) definition and in 46.6% using a length-of-stay-extended definition. Operative time and length of stay increased significantly with IWATE difficulty (p < 0.001 and p = 0.030), as did the composite failure endpoint (p = 0.039), whereas blood loss and complications did not. TOs decreased with difficulty under the extended definition (p = 0.016). No outcome except estimated blood loss differed across chronological tertiles (p = 0.032). Operative time was associated with the IWATE score (26.3 min per point; R2 = 0.32) but not with case order (p = 0.93). CUSUM and RA-CUSUM curves showed a non-linear, multiphase pattern without an identifiable inflection point, with extremes attributable to individual high-complexity procedures.

Conclusions

In this exploratory single-surgeon series, consisting predominantly of minor resections, no case-number threshold could be identified, and perioperative outcomes were more closely associated with procedural complexity than with chronological experience, supporting a complexity-adjusted interpretation of RLR outcomes rather than a fixed case-number learning threshold.

Для цитирования: Vella Roberta, Bici Kejd, Li Petri Sergio, Pagano Duilio, Bonsignore Pasquale, Tropea Alessandro, Calamia Sergio, Accardo Caterina, Vella Ivan, Vitale Irene, Chimenti Federica, Barbara Marco, di Francesco Fabrizio, Gruttadauria Salvatore. Perioperative Outcomes and Learning Curve for Robotic Liver Resection: An Exploratory Single-Surgeon CUSUM Analysis Stratified by IWATE Difficulty Score.. Cancers. 2026. DOI: 10.3390/cancers18172739.
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