Journal of orthopaedic surgery and research · 2019
Oral administration of Lactobacillus casei Shirota improves recovery of hand functions after distal radius fracture among elder patients: a placebo-controlled, double-blind, and randomized trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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История · было → стало
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Zhang Chunhua, Xue Sujuan, Wang Yong, Yu Dan, Hua Limei, Guo Chunhua, Wang Dawei, Lei Min
Аннотация
BACKGROUND: To evaluate the effect of oral Lactobacillus casei Shirota (LcS) administration on recovery of hand functions in senior patients diagnosed with an acute distal radius fracture.
METHODS: This clinical trial is double-blind and placebo-controlled, in which 293 senior patients with distal radius fracture were initially enrolled. After exclusion, 264 eligible patients were randomly assigned to receive oral placebo or LcS daily for a period of 3 months after the fracture. Treatment outcomes were Michigan Hand Questionnaire (MHQ) score, radial deviation and inclination, and ulnar deviation and variance, all of which were monitored and measured every month.
RESULTS: Throughout the length of this study, MHQ score, radial deviation and inclination, and ulnar deviation and variance of patients on oral LcS displayed a significantly faster improvement in comparison to those receiving placebo, over the 3-month intervention period.
CONCLUSION: Oral administration of LcS dramatically accelerated hand function recovery in senior patients with distal radius fracture.
METHODS: This clinical trial is double-blind and placebo-controlled, in which 293 senior patients with distal radius fracture were initially enrolled. After exclusion, 264 eligible patients were randomly assigned to receive oral placebo or LcS daily for a period of 3 months after the fracture. Treatment outcomes were Michigan Hand Questionnaire (MHQ) score, radial deviation and inclination, and ulnar deviation and variance, all of which were monitored and measured every month.
RESULTS: Throughout the length of this study, MHQ score, radial deviation and inclination, and ulnar deviation and variance of patients on oral LcS displayed a significantly faster improvement in comparison to those receiving placebo, over the 3-month intervention period.
CONCLUSION: Oral administration of LcS dramatically accelerated hand function recovery in senior patients with distal radius fracture.