Cocaine intoxication associated with abruptio placentae.

Acute cocaine intoxication has been associated with elevated blood pressure and placental abruption. A retrospective analysis was performed comparing gestational age at the time of placental abruption and response to conventional therapy for elevated blood pressure between patients known to have ingested cocaine and those who were drug free. Data suggest that cocaine ingestion during pregnancy increases the risk of early placental abruption and an elevation of blood pressure that is not as responsive to conventional therapy as pregnancy-induced hypertension.