Clinical Study of Recombinant Human Basic Fibroblast Growth Factor Combined With Collagen Sponge in the Treatment of Maxillofacial Degree II Acute Skin Contusion.

OBJECTIVE

To evaluate the clinical efficacy of recombinant human basic fibroblast growth factor (Rh-bFGF) combined with collagen sponge in the treatment of grade II acute maxillofacial abrasions.

METHODS

During the study period from September 2020 to September 2023, 128 such patients were in the authors' hospital and randomly divided into control group (N = 64) and experimental group (N = 64). The observation group was treated with Rh-bFGF and collagen sponge after debridement, while the control group was treated with vaseline gauze after debridement. The healing rate and healing time were observed, and the levels of TNF-α, IL-6, IL-10, EGF, VEGF, and Timp-1 were determined. The Vancouver Scar Scale (VSS) was used to evaluate the local scar hyperplasia 6 months after wound healing in both groups.

RESULTS

On the seventh and 14th day of treatment, the wound healing rate in the observation group was significantly higher than that in the control group ( P < 0.05), and the wound healing time in the observation group was lower than that in the control group ( P < 0.05), the levels of TNF-α, IL-6, EGF, VEGF, and Timp-1 in the observation group were lower than those in the control group ( P < 0.05), the levels of Il-10 were higher than those in the control group ( P < 0.05), and the levels of EGF, VEGF, and Timp-1 were higher than those in the control group ( P < 0.05). Vancouver Scar Scale score of local scar hyperplasia was significantly lower than that of control group ( P < 0.05).

CONCLUSIONS

Recombinant human basic fibroblast growth factor (Rh-bFGF) combined with collagen sponge in the treatment of maxillofacial contusion can decrease the levels of TNF-α and IL-6, increase the levels of IL-10 and effectively control inflammation, at the same time, it can increase the levels of EGF, VEGF, and Timp-1, promote wound healing and reduce scar hyperplasia. The therapeutic scheme is simple, safe, and effective, and suitable for clinical popularization and application.