Prolactin-producing pituitary adenomas.

Eight patients with amenorrhea, galactorrhea, and hyperprolactinemia underwent excision of pituitary adenomas by means of a microsurgical procedure that used a transsphenoidal approach. Prolactin values returned to normal in five of the patients and were significantly lower in three. Five patients resumed their menses. Two became pregnant. All eight patients had used oral contraceptives. The association of oral contraceptives and prolactin-producing pituitary adenomas is discussed.