Effectiveness of treating ovarian hyperstimulation syndrome with cabergoline in two patients with gonadotropin-producing pituitary adenomas.

OBJECTIVE

To report the effect of cabergoline on ovarian hyperstimulation syndrome associated with gonadotropin-secreting pituitary adenomas.

DESIGN

Case report.

SETTING

Outpatient practice.

PATIENT(S): Two women with menstrual irregularity, enlarged ovaries, high E(2), and normal gonadotropin levels.

INTERVENTION(S): Cabergoline treatment and transsphenoidal surgery.

MAIN OUTCOME MEASURE(S): Estradiol levels, transvaginal ultrasonography, and pituitary magnetic resonance imaging. Transsphenoidal surgery showed pituitary adenoma staining for LH in both patients.

RESULT(S): Cabergoline was effective in reducing E(2) levels and decreasing ovarian size but ineffective in shrinking the pituitary adenomas.

CONCLUSION(S): This is the first description of the effectiveness of cabergoline as the primary treatment of spontaneous ovarian hyperstimulation syndrome in patients with gonadotropin-producing pituitary adenomas.