Gynecologic oncology · 2026
Evaluating a patient ambassador program to improve clinical trial knowledge and intent to discuss gynecologic oncology trials.
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Ko Emily M, Pae Christine, Mulugeta-Gordon Lakeisha, Uwawaike Destiny, Elkins Katie, Chittams Jesse, Weldeab Nehemiah, Bilger Andrea, Ang Lee, Smith Anna Jo B, Guerra Carmen E
Аннотация
OBJECTIVE: We evaluated the implementation of a pilot patient-ambassador program designed to facilitate peer-to-peer discussion and education about gynecologic oncology (GYO) clinical trials among trial-naïve patients.
METHODS: We conducted a mixed-methods interventional behavioral study at an NCI designated comprehensive cancer center to assess a program initiating peer conversations about GYO clinical trials. From Feb-Oct 2024, patients who had previously participated in GYO clinical trials were recruited as ambassadors. Ambassadors completed a structured educational curriculum and were paired with 5-8 trial-naïve mentees with high-risk or advanced gynecologic cancers. Implementation outcomes included acceptability, feasibility, net promotor score, clinical trials knowledge, confidence discussing trials, and perception of trials. Qualitative analyses of recorded chats, and ambassador feedback were also performed.
RESULTS: Three ambassadors and 20 mentees completed the program, generating 20 "chats" from 266 eligible mentees. At baseline, 90% of mentees had heard of clinical trials and 75% reported somewhat or very positive perceptions. Post chat, 90% reported somewhat or very positive perceptions, 85% felt the chat changed their view of trials, and 95% felt confident to ask their oncology provider about trials. Although overall survey-based knowledge did not improve, 95% reported the chats were educational and addressed concerns. Acceptability, feasibility, and program promotion were high. Implementation challenges included emotional strain on ambassadors, mismatched expectations, and variability in discussing recruitment of diverse populations.
CONCLUSIONS: This pilot patient-ambassador program is a feasible and acceptable intervention that improved patient confidence in discussing clinical trials with providers.
METHODS: We conducted a mixed-methods interventional behavioral study at an NCI designated comprehensive cancer center to assess a program initiating peer conversations about GYO clinical trials. From Feb-Oct 2024, patients who had previously participated in GYO clinical trials were recruited as ambassadors. Ambassadors completed a structured educational curriculum and were paired with 5-8 trial-naïve mentees with high-risk or advanced gynecologic cancers. Implementation outcomes included acceptability, feasibility, net promotor score, clinical trials knowledge, confidence discussing trials, and perception of trials. Qualitative analyses of recorded chats, and ambassador feedback were also performed.
RESULTS: Three ambassadors and 20 mentees completed the program, generating 20 "chats" from 266 eligible mentees. At baseline, 90% of mentees had heard of clinical trials and 75% reported somewhat or very positive perceptions. Post chat, 90% reported somewhat or very positive perceptions, 85% felt the chat changed their view of trials, and 95% felt confident to ask their oncology provider about trials. Although overall survey-based knowledge did not improve, 95% reported the chats were educational and addressed concerns. Acceptability, feasibility, and program promotion were high. Implementation challenges included emotional strain on ambassadors, mismatched expectations, and variability in discussing recruitment of diverse populations.
CONCLUSIONS: This pilot patient-ambassador program is a feasible and acceptable intervention that improved patient confidence in discussing clinical trials with providers.