Ceftriaxone induced pancreatitis: A case report with review of literature.

INTRODUCTION

Ceftriaxone is a widely used third-generation cephalosporin that is generally well tolerated. However, rare complications such as acute pancreatitis may occur, potentially due to the precipitation of ceftriaxone in the bile.

CASE OBSERVATION: We report the case of a 62-year-old man diagnosed with a urinary tract infection and treated with intravenous ceftriaxone. On the eighth day of treatment, the patient developed dyspepsia, nausea, epigastric pain, and fever. Laboratory tests revealed elevated levels of lipase and amylase, and abdominal computed tomography confirmed a diagnosis of acute pancreatitis. Suspecting a ceftriaxone-induced adverse reaction, the antibiotic was discontinued. Within 72 hours, laboratory values normalized and clinical symptoms resolved.

CONCLUSION

Although rare, clinicians should consider ceftriaxone as a potential cause of acute pancreatitis, especially when no other causes are evident. Prompt discontinuation of the drug typically results in rapid clinical and biochemical improvement.