International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 1995
CA 125, CA 15.3, CA 27.29, CEA, beta-hCG and alpha-fetoprotein levels in cyst fluid of breast macrocysts.
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Martínez L, Castilla J A, Blanco N, Perán F, Herruzo A
Аннотация
OBJECTIVE: To determine the tumoral markers CA 125, CA 15.3, CA 27.29, CEA, beta-hCG and alpha-fetoprotein in serum and breast cystic fluid in women with fibrocystic breast disease.
METHODS: The study comprised 50 women diagnosed with fibrocystic breast disease but without breast macrocysts, and 60 women with macrocysts.
RESULTS: Significantly higher levels of CA 125, CA 27.29, beta-hCG and CEA were observed in the cyst fluid than in the serum of the same patients. According to their K+/Na+ quotient we found that when K+/Na+ was < 3, cyst fluid CA 125, CA 27.29, beta-hCG and CEA levels were significantly higher than serum levels. However, when K+/Na+ was > 3, only CA 27.29 and beta-hCG levels were significantly higher. Comparing cyst fluid marker levels with respect to the K+/Na+ ratio, the only difference observed was in CA 125 which was significantly greater when K+/Na+ was < 3. A negative correlation was found between CA 125 and the K+/Na+ quotient.
CONCLUSION: These results suggest that CA 125 could be used as a marker to identify cyst type.
METHODS: The study comprised 50 women diagnosed with fibrocystic breast disease but without breast macrocysts, and 60 women with macrocysts.
RESULTS: Significantly higher levels of CA 125, CA 27.29, beta-hCG and CEA were observed in the cyst fluid than in the serum of the same patients. According to their K+/Na+ quotient we found that when K+/Na+ was < 3, cyst fluid CA 125, CA 27.29, beta-hCG and CEA levels were significantly higher than serum levels. However, when K+/Na+ was > 3, only CA 27.29 and beta-hCG levels were significantly higher. Comparing cyst fluid marker levels with respect to the K+/Na+ ratio, the only difference observed was in CA 125 which was significantly greater when K+/Na+ was < 3. A negative correlation was found between CA 125 and the K+/Na+ quotient.
CONCLUSION: These results suggest that CA 125 could be used as a marker to identify cyst type.
Предметные рубрики MeSH
17-alpha-HydroxyprogesteroneAdolescentAdultAntigens, NeoplasmAntigens, Tumor-Associated, CarbohydrateBiomarkers, TumorBiopsy, NeedleCA-125 AntigenCarcinoembryonic AntigenChorionic GonadotropinChorionic Gonadotropin, beta Subunit, HumanDehydroepiandrosteroneDehydroepiandrosterone SulfateEstradiolExudates and TransudatesFemaleFibrocystic Breast DiseaseHumansHydroxyprogesteronesMiddle AgedMucin-1Peptide FragmentsPotassiumProgesteroneRegression AnalysisSodiumTestosteronealpha-Fetoproteins