Suzetrigine for moderate to severe acute pain.

Suzetrigine (VX-548), 2-pyridinecarboxamide, 4-[[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]-, or 4-[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)oxolane-2-carbonyl]amino]pyridine-2-carboxamide, is a selective voltage-gated sodium channel NaV1.8 blocker that was recently approved by FDA as a non-opioid analgesic to treat moderate to severe acute pain. It has a molecular formula C21H20F5N3O4 and a molecular weight of 473.4 g/mol. The molecule has a chiral tetrahydrofuran core (2R,3S,4S,5R) that is conjugated to a picolinamide ring via an amide linker at position 2, a 3,4-difluoro-2-methoxyphenyl group at position 3, a methyl group at position 4, and both a trifluoromethyl group and a methyl group at position 5.