Metoprolol in Chronic Obstructive Pulmonary Disease without Cardiovascular Disease.
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Sundh Josefin, Magnuson Anders, Kvarnström Marika, Sjöberg Folke, Ekström Magnus, Berglund Johan SanMartin, Ellingsen David, Wilhelms Daniel, Hasselgren Mikael, Cesarini Sara Fristorp, Blom Katarina Berndtsson, Blomberg Anders, Vanfleteren Lowie E G W, Palm Andreas, Smith Carolina, Renström Lina, Ellingsen Jens, Janson Christer, Lundvall Martin, Delijaj Florim, Norberg Elsa, Larsson Beatrice, Kipper Taivo, Chowdhury Zaky, Jensen Emily, Stenberg Henning, Hårdstedt Maria, Ahmadi Zainab, Azizi Kaveh, Greger Wolfgang, Montgomery Scott, Fröbert Ole
Аннотация
METHODS: This was a multicenter, open-label, pragmatic, phase 4 randomized trial. Patients 40 years of age or older with COPD, sinus rhythm, and no cardiovascular disease were randomly assigned in a 1:1 ratio to receive metoprolol, at a target dose of 100 mg daily, in addition to standard care or to receive standard care alone. The primary end point was the time to the first occurrence of a COPD exacerbation, cardiovascular event, or death during 1 year of follow-up.
RESULTS: A total of 1695 patients underwent random assignment; their mean age was 70 years, and 62% were female. The primary end point occurred in 27% of patients assigned to receive metoprolol and in 30% assigned to receive standard care (hazard ratio, 0.87; 95% confidence interval [CI], 0.73 to 1.05; P=0.14). The corresponding hazard ratios were 0.88 (95% CI, 0.72 to 1.06) for COPD exacerbations, 0.73 (95% CI, 0.48 to 1.11) for cardiovascular events, 0.92 (95% CI, 0.48 to 1.77) for death, and 0.87 (95% CI, 0.58 to 1.28) for exacerbations requiring hospitalization. Serious adverse events occurred in 80 (9.4%) of 848 participants in the metoprolol group and 66 (7.8%) of 847 participants in the standard care group. Nonserious adverse events occurred in 293 (34.6%) of 848 patients in the metoprolol group and 247 (29.2%) of 847 in the standard care group.
CONCLUSIONS: Among patients with COPD and no cardiovascular disease, metoprolol did not significantly improve the time to a composite of exacerbations, cardiovascular events, or death. (Funded by research grants from the Swedish Research Council and others; ClinicalTrials.gov number, NCT03566667.).