The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception · 2007
Effect of depot medroxyprogesterone acetate on bone density in a Scottish industrial city.
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McGough Pauline, Bigrigg Alison
Аннотация
OBJECTIVE: To determine if long-term users of depot medroxyprogesterone acetate injectable contraception (DMPA) were more likely than their peers to have low bone density.
DESIGN: Cross-sectional observational study.
SETTING: The Domiciliary Family Planning Service, Glasgow, Scotland.
SUBJECTS: Clients of the Domiciliary Service who had used DMPA for contraception for longer than 5 years (mean 12 years) were invited to participate and select their own control, a friend or relative who had never used this method of contraception.
MAIN OUTCOME MEASURES: Bone density measured at the hip and lumbar spine by dual X-ray absorptiometry (DXA).
RESULTS: DMPA users had a significantly lower bone density than controls, 12-13% less at both hip and lumbar spine. This difference remained even when controlling for parity, smoking, family history of kyphosis or hip fracture, and body mass index.
CONCLUSIONS: DMPA significantly decreases bone density in a group of long-term users with significant social deprivation. The long-term significance of this remains uncertain.
DESIGN: Cross-sectional observational study.
SETTING: The Domiciliary Family Planning Service, Glasgow, Scotland.
SUBJECTS: Clients of the Domiciliary Service who had used DMPA for contraception for longer than 5 years (mean 12 years) were invited to participate and select their own control, a friend or relative who had never used this method of contraception.
MAIN OUTCOME MEASURES: Bone density measured at the hip and lumbar spine by dual X-ray absorptiometry (DXA).
RESULTS: DMPA users had a significantly lower bone density than controls, 12-13% less at both hip and lumbar spine. This difference remained even when controlling for parity, smoking, family history of kyphosis or hip fracture, and body mass index.
CONCLUSIONS: DMPA significantly decreases bone density in a group of long-term users with significant social deprivation. The long-term significance of this remains uncertain.
Предметные рубрики MeSH
Absorptiometry, PhotonAdultAnalysis of VarianceBody Mass IndexBone DensityCase-Control StudiesContraceptive Agents, FemaleCross-Sectional StudiesDelayed-Action PreparationsEstradiolFamily Planning ServicesFemaleFemur NeckHumansLinear ModelsLumbar VertebraeMedroxyprogesterone AcetateMiddle AgedObservationOsteopetrosisPoverty AreasScotlandUrban HealthWhite People