Genes & diseases · 2020
Notch signaling: Its essential roles in bone and craniofacial development.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Pakvasa Mikhail, Haravu Pranav, Boachie-Mensah Michael, Jones Alonzo, Coalson Elam, Liao Junyi, Zeng Zongyue, Wu Di, Qin Kevin, Wu Xiaoxing, Luo Huaxiu, Zhang Jing, Zhang Meng, He Fang, Mao Yukun, Zhang Yongtao, Niu Changchun, Wu Meng, Zhao Xia, Wang Hao, Huang Linjuan, Shi Deyao, Liu Qing, Ni Na, Fu Kai, Lee Michael J, Wolf Jennifer Moriatis, Athiviraham Aravind, Ho Sherwin S, He Tong-Chuan, Hynes Kelly, Strelzow Jason, El Dafrawy Mostafa, Reid Russell R
Аннотация
Notch is a cell-cell signaling pathway that is involved in a host of activities including development, oncogenesis, skeletal homeostasis, and much more. More specifically, recent research has demonstrated the importance of Notch signaling in osteogenic differentiation, bone healing, and in the development of the skeleton. The craniofacial skeleton is complex and understanding its development has remained an important focus in biology. In this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton, skull, and face develop. We then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system, and what importance it may play in the future.