Disseminated Magnusiomyces clavatus (Geotrichum clavatum) infection following allogenic stem cell transplantation: a case report.

BACKGROUND

Magnusiomyces clavatus (formerly Geotrichum clavatum/Saprochaete clavata) is a yeast with a filamentous form, as well as an uncommon, yet emerging opportunistic pathogen. It occurs primarily in patients experiencing prolonged neutropenia, and there is limited evidence available to guide antifungal agent selection and treatment decisions.

CASE SUMMARY: We present a case of disseminated infection caused by M. clavatus in a patient with myelofibrosis following allogeneic hematopoietic stem cell transplantation. The patient was treated with voriconazole, as well as liposomal amphotericin B, along with granulocyte transfusion. The patient died from persistent fungemia, refractory septic shock, and multiorgan failure 20 days after the infection was first diagnosed.

CONCLUSION

We subsequently discuss the epidemiological, clinical, and therapeutic features of this severe fungal infection and present a review of currently available literature.