Materials science & engineering. C, Materials for biological applications · 2013
Antibiotic-loaded acrylic bone cements: an in vitro study on the release mechanism and its efficacy.
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Miola Marta, Bistolfi Alessandro, Valsania Maria Carmen, Bianco Carlotta, Fucale Giacomo, Verné Enrica
Аннотация
An in vitro study was carried out in order to investigate the antibiotic release mechanism and the antibacterial properties of commercially (Palacos® R+G and Palacos® LV+G) and manually (Palacos® R+GM and Palacos® LV+GM) blended gentamicin-loaded bone cements. Samples were characterized by means of scanning electron microscopy (SEM) and compression strength was evaluated. The antibiotic release was investigated by dipping sample in simulated body fluid (SBF) and periodically analyzing the solution by means of high pressure liquid chromatography (HPLC). Different antibacterial tests were performed to investigate the possible influence of blending technique on antibacterial properties. Only some differences were observed between gentamicin manually added and commercial ones, in the release curves, while the antibacterial effect and the mechanical properties seem to not feel the blending technique.