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Войти в исследования Clinical impact of urinary CD11b and CD163 on the renal outcomes of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.
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Yokoe Yuki, Tsuboi Naotake, Imaizumi Takahiro, Kitagawa Akimitsu, Karasawa Munetoshi, Ozeki Takaya, Endo Nobuhide, Sawa Yuriko, Kato Sawako, Katsuno Takayuki, Maruyama Shoichi, Yamagata Kunihiro, Usui Joichi, Nagata Michio, Sada Ken-Ei, Sugiyama Hitoshi, Amano Koichi, Arimura Yoshihiro, Atsumi Tatsuya, Yuzawa Yukio, Dobashi Hiroaki, Takasaki Yoshinari, Harigai Masayoshi, Hasegawa Hitoshi, Makino Hirofumi, Matsuo Seiichi, Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis and for Intractable Renal Disease
Аннотация
METHODS: U-CD11b and U-CD163 were examined using enzyme-linked immunosorbent assay in ANCA-GN urine samples from our institutional cohort (n = 88) and a nationwide cohort (n = 138), and their association with renal histology was subsequently analyzed. Logistic regression analyses were performed on a nationwide ANCA cohort to determine the associations of the two urinary molecules with renal remission failure at 6 months or with yearly estimated glomerular filtration rate (eGFR) slope over a 24-month observation period.
RESULTS: U-CD11b and U-CD163 were significantly associated with cellular crescent formation and leukocyte accumulation in glomerular crescents. With regard to interstitial inflammation, both levels of U-CD11b and U-CD163 at diagnosis remarkably increased in ANCA-GN compared with the levels observed in nonglomerular kidney disorders including nephrosclerosis, immunoglobulin G4-related disease and tubulointerstitial nephritis; however, the presence of U-CD11b alone was significantly correlated with tubulointerstitial leukocyte infiltrates. Although neither U-CD11b nor U-CD163 at diagnosis was associated with remission failure at 6 months, multivariate analysis demonstrated that the baseline U-CD11b levels were significantly associated with the increase in eGFR following immunosuppressive therapy.
CONCLUSIONS: Although both U-CD11b and U-CD163 reflect renal leukocyte accumulation, U-CD11b at diagnosis provides additional clinical value by predicting the recovery rate after the treatment of ANCA-GN.