Recent advances in reproductive biology: European innovations in embryo development and research†.

European research has played a pioneering role in advancing reproductive biology and embryology, contributing transformative innovations in assisted reproductive technologies (ARTs). Landmark achievements-from the development of artificial insemination and sperm cryopreservation to in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI)-have dramatically improved fertility outcomes in both humans and animals. These breakthroughs have enabled increased reproductive success, genetic gain, and productivity in livestock, while also addressing the global burden of infertility in humans. Central to recent progress is the application of high-throughput single-cell RNA sequencing, which has revealed conserved and species-specific molecular pathways during early embryonic development. Parallel efforts have led to the development of synthetic embryo models, showcasing the self-organizing capacity of pluripotent cells and offering alternatives to natural embryo studies, particularly in species where embryo availability is limited. These models recapitulate key developmental milestones and are informed by high-resolution single-cell atlases of multiple species, many of which were created in European institutions. While notable advances have been made, challenges persist in achieving reproducibility and more robust implantation models. Nevertheless, the integration of genomic, stem cell, and bioengineering technologies continues to expand the frontiers of reproductive biology. This review highlights Europe's significant contributions to embryological research and outlines the emerging tools and challenges shaping the future of reproductive science.