Journal of minimally invasive gynecology · 2026
Correlation Between Hysteroscopic Findings and Histopathological Evidence of Chronic Endometritis in Reproductive Age Women With Gynecological Disorders.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Rana Ashu, Nigam Aruna, Chaubey Supriya, Jetley Sujata, Gupta Nidhi, Roy Pratibha, Sharma Sumedha
Аннотация
STUDY OBJECTIVE: To correlate 12 predefined hysteroscopic endometrial features with histopathological plasma cell grading (H&E) and dual immunohistochemical expression of CD138 and MUM-1 in reproductive-age women presenting with abnormal uterine bleeding (AUB), infertility, or recurrent pregnancy loss (RPL) at a tertiary care center in India, and to evaluate whether chronic endometritis (CE) prevalence differs across these 3 clinical indications.
DESIGN: Prospective cross-sectional observational study.
SETTING: Tertiary care academic hospital, New Delhi, India.
PATIENTS: Seventy consecutive women of reproductive age presenting with AUB (n = 40, 57.1%), infertility (n = 22, 31.4%), or RPL (n = 8, 11.4%), fulfilling predefined eligibility criteria, who underwent hysteroscopy with directed endometrial biopsy over 1.5 years.
INTERVENTIONS: Assessment of 12 predefined hysteroscopic features between days 7 to 11 of the menstrual cycle, followed by directed endometrial biopsy subjected to immunohistochemical (IHC) expression of CD138 (syndecan-1, a surface marker of fully differentiated plasma cells) and MUM-1 (IRF4, a nuclear marker active across late B-cell differentiation into plasma cells).
MEASUREMENTS AND MAIN RESULTS: CD138 positivity was identified in 90.0% of participants (low-grade 60.0%; high-grade 30.0%); MUM-1 in 74.3% (low-grade 50.0%; high-grade 24.3%). On H&E, Grade 1 plasma cell infiltration (PC-1) was present in 40.0% and Grade 2 in 14.3%. Micropolyps were significantly associated with Grade 2 plasma cell infiltration (PC-2) (p = .040; OR = 4.89, 95% CI 0.96-24.97) and CD138 high positivity (p = .019; OR = 3.63, 95% CI 1.20-10.94). Hysteroscopic evidence of endometrial hyperplasia correlated with PC-2 (p = .027; Cramér's V = 0.284). Localized hyperemia was associated with MUM-1 low positivity (χ² = 8.70, df = 2, p = .013). CE prevalence did not differ significantly across clinical subgroups (all p >.05). No granulomatous endometritis was identified.
CONCLUSIONS: CE is common and equally prevalent across AUB, infertility, and RPL presentations at this center. Micropolyps and endometrial hyperplasia are the most informative hysteroscopic predictors of high-grade CE. CD138 is the more sensitive marker; MUM-1 adds complementary value by identifying earlier-stage B-lineage activation. Hysteroscopy with directed biopsy and dual CD138/MUM-1 immunohistochemistry is the recommended diagnostic approach.
DESIGN: Prospective cross-sectional observational study.
SETTING: Tertiary care academic hospital, New Delhi, India.
PATIENTS: Seventy consecutive women of reproductive age presenting with AUB (n = 40, 57.1%), infertility (n = 22, 31.4%), or RPL (n = 8, 11.4%), fulfilling predefined eligibility criteria, who underwent hysteroscopy with directed endometrial biopsy over 1.5 years.
INTERVENTIONS: Assessment of 12 predefined hysteroscopic features between days 7 to 11 of the menstrual cycle, followed by directed endometrial biopsy subjected to immunohistochemical (IHC) expression of CD138 (syndecan-1, a surface marker of fully differentiated plasma cells) and MUM-1 (IRF4, a nuclear marker active across late B-cell differentiation into plasma cells).
MEASUREMENTS AND MAIN RESULTS: CD138 positivity was identified in 90.0% of participants (low-grade 60.0%; high-grade 30.0%); MUM-1 in 74.3% (low-grade 50.0%; high-grade 24.3%). On H&E, Grade 1 plasma cell infiltration (PC-1) was present in 40.0% and Grade 2 in 14.3%. Micropolyps were significantly associated with Grade 2 plasma cell infiltration (PC-2) (p = .040; OR = 4.89, 95% CI 0.96-24.97) and CD138 high positivity (p = .019; OR = 3.63, 95% CI 1.20-10.94). Hysteroscopic evidence of endometrial hyperplasia correlated with PC-2 (p = .027; Cramér's V = 0.284). Localized hyperemia was associated with MUM-1 low positivity (χ² = 8.70, df = 2, p = .013). CE prevalence did not differ significantly across clinical subgroups (all p >.05). No granulomatous endometritis was identified.
CONCLUSIONS: CE is common and equally prevalent across AUB, infertility, and RPL presentations at this center. Micropolyps and endometrial hyperplasia are the most informative hysteroscopic predictors of high-grade CE. CD138 is the more sensitive marker; MUM-1 adds complementary value by identifying earlier-stage B-lineage activation. Hysteroscopy with directed biopsy and dual CD138/MUM-1 immunohistochemistry is the recommended diagnostic approach.