Dietary Fiber-Phenolic Milk Tablets Are Associated with Improved Lipid Profiles and Reduced Circulating HMGCR Levels in Hypercholesterolemic Subjects: An Open-Label Pre-Post Study.

Modulation of cholesterol metabolism and reduction in serum cholesterol are key strategies for preventing cardiovascular diseases (CVDs). Functional foods enriched with dietary fiber and phytochemicals have attracted increasing attention for their potential health benefits. In this study, milk tablets containing kale and carrot (KC) were developed and preliminarily evaluated for their cholesterol-lowering potential. KC milk tablets were rich in dietary fiber, contained gallic acid, and exhibited antioxidant properties. They also supported the growth of Lactobacillus casei and Bifidobacterium longum in vitro, accompanied by increased SCFA production. In an open-label, pre-post exploratory study in hypercholesterolemic subjects, daily consumption for 6 weeks was associated with significantly increased HDL-C and reduced LDL-C levels. In addition, circulating ApoB100 and HMGCR levels were reduced, whereas ApoE and TNF-α remained unchanged. Therefore, these preliminary findings suggest that KC milk tablets may accomplish beneficial changes in lipid profiles and support the potential of dietary fiber-phenolic interactions with enhanced SCFA production which might modulate cholesterol metabolism. However, in further studies, randomized controlled trials are required to understand the precise underlying mechanism.