A Quick Reference on High Anion Gap Metabolic Acidosis.

High anion gap metabolic acidosis is marked by decreased blood pH and bicarbonate concentration, with normal chloride levels and compensatory hypocapnia. It results from the accumulation of strong acids such as ketoacids, lactic acid (L- and D-isoforms), uremic acids, or toxins like ethylene glycol. Elevated inorganic phosphate may also contribute. Clinical manifestations typically reflect the underlying disorder rather than the acidosis itself. Management focuses on identifying and treating the primary disease process.