Multiple sclerosis journal - experimental, translational and clinical · 2026
The constrained brain in multiple sclerosis: Cognitive impairment is related to network-specific coupling of structural and functional connectivity.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bet Marloes DA, van Dam Maureen, Broeders Tommy Aa, Ruet Aurélie, Barkhof Frederik, Strijbis Eva Mm, Douw Linda, Koubiyr Ismail, Hulst Hanneke E, Schoonheim Menno M
Аннотация
BACKGROUND: Cognitive impairment in multiple sclerosis (MS) is related to abnormal structural and functional brain network changes. As both modalities have mostly been studied separately, structure connectivity-function coupling (SC-FC) may elucidate how function is constrained by structure.
OBJECTIVES: We examine how changes in SC-FC and its dynamics SC-FC (dSC-FC) may underlie MS-related cognitive impairment.
METHODS: We classified 266 people with MS (PwMS) as cognitively impaired (CI; z < -2 on ≥2/7 cognitive abilities compared to healthy controls [HC]) or preserved (CP; z > -1.5 on ≥2/7 abilities). Derived from diffusion-weighted and functional magnetic resonance imaging, SC-FC reflected the correlation coefficient between structural and functional connectivity, while dSC-FC reflected its variability. Whole-brain, within-network, and between-network (d)SC-FC were compared between 95 HC, 197 CP, and 69 CI.
RESULTS: Compared to CP and HC, CI showed higher SC-FC for connections extending from the dorsal attention (DAN; p ≤ 0.006) and somatomotor networks (p ≤ 0.024), and higher dSC-FC within the visual network (p ≤ 0.003) and deep grey matter (p ≤ 0.006). SC-FC in connections extending from the DAN predicted CP/CI status in PwMS (β = 0.069, OR = 1.072 [95% CI = 1.009-1.139], p = 0.025).
CONCLUSIONS: In MS-related CI, deterioration of structural pathways is paired with loss of functional strength in connections extending from the DAN. This may hinder DAN-mediated stimulus selection, possibly contributing to CI.
OBJECTIVES: We examine how changes in SC-FC and its dynamics SC-FC (dSC-FC) may underlie MS-related cognitive impairment.
METHODS: We classified 266 people with MS (PwMS) as cognitively impaired (CI; z < -2 on ≥2/7 cognitive abilities compared to healthy controls [HC]) or preserved (CP; z > -1.5 on ≥2/7 abilities). Derived from diffusion-weighted and functional magnetic resonance imaging, SC-FC reflected the correlation coefficient between structural and functional connectivity, while dSC-FC reflected its variability. Whole-brain, within-network, and between-network (d)SC-FC were compared between 95 HC, 197 CP, and 69 CI.
RESULTS: Compared to CP and HC, CI showed higher SC-FC for connections extending from the dorsal attention (DAN; p ≤ 0.006) and somatomotor networks (p ≤ 0.024), and higher dSC-FC within the visual network (p ≤ 0.003) and deep grey matter (p ≤ 0.006). SC-FC in connections extending from the DAN predicted CP/CI status in PwMS (β = 0.069, OR = 1.072 [95% CI = 1.009-1.139], p = 0.025).
CONCLUSIONS: In MS-related CI, deterioration of structural pathways is paired with loss of functional strength in connections extending from the DAN. This may hinder DAN-mediated stimulus selection, possibly contributing to CI.