Kidney international reports · 2026
APOL1 Variants, AKI, and Progression to Kidney Failure in People of African Ancestry Living with HIV.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hung Rachel K Y, Booth John W, Hilton Rachel, Campbell Lucy, Fox Julie, Ustianowski Andrew, Clarke Amanda, Hamzah Lisa, Schoeman Sarah, Bramham Kate, Burns Fiona, Okhai Hajra, Sabin Caroline A, Winkler Cheryl A, Post Frank A, GEN-AFRICA Study Group
Аннотация
INTRODUCTION: Acute kidney injury (AKI) is a common complication of HIV infection and associated with progression to kidney failure. We investigated associations between Apolipoprotein L1 (APOL1) variants and AKI, and between AKI, APOL1 variants and incident kidney failure, in people of African ancestry with HIV.
METHODS: We conducted a retrospective analysis of AKI (Kidney Disease: Improving Global Outcomes stages 2/3 and 3) in Genetic Markers of Kidney Disease Progression in People of African Ancestry with HIV (GEN-AFRICA) participants stratified by APOL1 genotype (2 [G1G1, G1G2, G2G2], 1 [G1G0, G2G0] or 0 [G0G0] variants). Robust Poisson regression estimated AKI prevalence ratios (PR) within 3 months of cohort inception. Poisson regression with generalized estimating equations estimated AKI incidence rate ratios (IRR) during follow-up, adjusting for sex, age, time-updated cluster of differentiation 4 (CD4) count, HIV viral load, and kidney function. Cox proportional hazards models examined associations between AKI, APOL1 variants, and incident kidney failure.
RESULTS: Among 2701 participants (43% male; mean age 38.7 years; 12.7% with 2 APOL1 variants), 165 individuals experienced 183 AKI episodes. Participants with 2 APOL1 variants were more likely to experience AKI at cohort inception (adjusted PR 6.9, 95% CI: 3.5-13.8, P < 0.001), had more severe AKI, and poorer recovery of kidney function post-AKI compared with those with 0 variants, but not during follow up. AKI was associated with incident kidney failure and this association varied by APOL1 status (P interaction < 0.001).
CONCLUSION: Among people with HIV, 2 APOL1 variants were associated with increased risk of AKI, especially severe AKI at cohort inception, and poorer recovery of post-AKI. AKI identified individuals at increased risk of progression to kidney failure.
METHODS: We conducted a retrospective analysis of AKI (Kidney Disease: Improving Global Outcomes stages 2/3 and 3) in Genetic Markers of Kidney Disease Progression in People of African Ancestry with HIV (GEN-AFRICA) participants stratified by APOL1 genotype (2 [G1G1, G1G2, G2G2], 1 [G1G0, G2G0] or 0 [G0G0] variants). Robust Poisson regression estimated AKI prevalence ratios (PR) within 3 months of cohort inception. Poisson regression with generalized estimating equations estimated AKI incidence rate ratios (IRR) during follow-up, adjusting for sex, age, time-updated cluster of differentiation 4 (CD4) count, HIV viral load, and kidney function. Cox proportional hazards models examined associations between AKI, APOL1 variants, and incident kidney failure.
RESULTS: Among 2701 participants (43% male; mean age 38.7 years; 12.7% with 2 APOL1 variants), 165 individuals experienced 183 AKI episodes. Participants with 2 APOL1 variants were more likely to experience AKI at cohort inception (adjusted PR 6.9, 95% CI: 3.5-13.8, P < 0.001), had more severe AKI, and poorer recovery of kidney function post-AKI compared with those with 0 variants, but not during follow up. AKI was associated with incident kidney failure and this association varied by APOL1 status (P interaction < 0.001).
CONCLUSION: Among people with HIV, 2 APOL1 variants were associated with increased risk of AKI, especially severe AKI at cohort inception, and poorer recovery of post-AKI. AKI identified individuals at increased risk of progression to kidney failure.