Dynamic Kinetic Asymmetric P-C Coupling of Secondary Phosphine Oxides with Alkenyl Iodides.

Transition metal-catalyzed enantioselective P-C bond-forming reactions between racemic secondary phosphine oxides (SPOs) and various electrophiles have emerged as powerful strategies for accessing P-chiral compounds. However, most reported transformations proceeded via kinetic resolution of SPOs, inherently limiting efficiency. In contrast, dynamic kinetic asymmetric coupling enables full conversion of racemic SPOs─offering a more effective pathway─yet such methods remain rare. Herein, we report the first dynamic kinetic asymmetric P-C coupling of SPOs with alkenyl iodides. This transformation, enabled by a copper catalyst bearing a novel chiral 1,2-diamine ligand, affords a broad range of P-chiral tertiary phosphine oxides in good yields and with high enantioselectivity.