American journal of translational research · 2026
Balloon dilatation combined with thrombectomy reduces myocardial injury in massive pulmonary embolism.
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Zheng Yi, Deng Jun, Zhou Senlin, Cao Chunli, Chen Gang, Li Siming, Ye Maolin, Deng Liang, Li Lin, Li Hai
Аннотация
OBJECTIVES: To investigate the alterations in myocardial injury markers following balloon dilatation combined with thrombectomy in patients with massive pulmonary embolism (MPE).
METHODS: A retrospective study was conducted in 90 patients diagnosed with MPE. Clinical efficacy, Miller scores, pulmonary artery pressure (PAP), pulmonary artery diameter (PAD), and levels of myocardial injury markers were evaluated and compared between the combined treatment group (balloon dilatation plus thrombectomy) and the basic treatment group (basic therapy alone).
RESULTS: Compared to the basic treatment group, the combined treatment group exhibited significantly improved clinical efficacy, including higher rates of complete response, marked response, and overall response. Hemodynamic and cardiac function indices were significantly improved, as evidenced by lower post-treatment Miller score, PAP, PAD, and right ventricular/left ventricular (RV/LV) ratios. Myocardial injury and inflammation-related indicators, including myoglobin (MYO), troponin T (TnT), creatine kinase (CK), and fibrinogen (FIB) were significantly reduced at specific time points in the combined treatment group. Furthermore, significant correlations were identified between injury markers and arterial blood gas indices: CK at 24 hours was inversely correlated with arterial partial pressure of carbon dioxide (PaCO2), and TnT at 72 hours was negatively associated with arterial partial pressure of oxygen (PaO2).
CONCLUSION: Balloon dilation combined with thrombectomy for the treatment of MPE can significantly reduce myocardial injury and inflammation-related indicators, thereby markedly improving clinical outcome.
METHODS: A retrospective study was conducted in 90 patients diagnosed with MPE. Clinical efficacy, Miller scores, pulmonary artery pressure (PAP), pulmonary artery diameter (PAD), and levels of myocardial injury markers were evaluated and compared between the combined treatment group (balloon dilatation plus thrombectomy) and the basic treatment group (basic therapy alone).
RESULTS: Compared to the basic treatment group, the combined treatment group exhibited significantly improved clinical efficacy, including higher rates of complete response, marked response, and overall response. Hemodynamic and cardiac function indices were significantly improved, as evidenced by lower post-treatment Miller score, PAP, PAD, and right ventricular/left ventricular (RV/LV) ratios. Myocardial injury and inflammation-related indicators, including myoglobin (MYO), troponin T (TnT), creatine kinase (CK), and fibrinogen (FIB) were significantly reduced at specific time points in the combined treatment group. Furthermore, significant correlations were identified between injury markers and arterial blood gas indices: CK at 24 hours was inversely correlated with arterial partial pressure of carbon dioxide (PaCO2), and TnT at 72 hours was negatively associated with arterial partial pressure of oxygen (PaO2).
CONCLUSION: Balloon dilation combined with thrombectomy for the treatment of MPE can significantly reduce myocardial injury and inflammation-related indicators, thereby markedly improving clinical outcome.