International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
Diagnostic accuracy, satisfaction, and acceptability of point-of-care testing for syphilis, hepatitis B, and hepatitis C infections among Thai adolescents and young adults with sexual risk behaviors.
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Chanthowong Chatdanai, Mueangmo Oramai, Saheng Jutamad, Wongjak Worawan, Chaito Tanachot, Sudjaritruk Tavitiya
Аннотация
BACKGROUND: Sexually transmitted infections (STIs) remain an important public health concern globally. This study evaluated the diagnostic performance of point-of-care tests (POCTs) for syphilis, hepatitis B virus (HBV), and hepatitis C virus (HCV) infections using capillary whole blood and venous plasma, and assessed acceptability of finger-prick-based POCTs among Thai adolescents and young adults (AYA).
METHODS: A cross-sectional diagnostic study was conducted among AYA aged 15-30 years with sexual risk behaviors attending a community sexual health clinic in Chiang Mai, Thailand. Several POCTs were evaluated for syphilis, HBV, and HCV using finger-prick capillary whole blood and venipuncture-derived plasma. Diagnostic performance was assessed against confirmatory reference assays. Participant satisfaction and acceptability of finger-prick-based POCTs were evaluated using a self-administered questionnaire.
RESULTS: Three hundred fifty high-risk Thai AYA (median age 23 years, 92% male, 71% self-identified as homosexual) were enrolled. Overall, 64% inconsistently used condoms, and 40% reported a lifetime history of STIs. The prevalence of seroactive syphilis, HBV, and HCV was 17%, 1%, and 4%, respectively. Finger-prick-based POCTs showed high diagnostic accuracy (92%-100% sensitivity and 90%-93% specificity for syphilis; 75% sensitivity and 99% specificity for HBV; 80% sensitivity and 99% specificity for HCV), comparable to venipuncture-based POCTs (87%-100% sensitivity and 92%-94% specificity for syphilis; 75% sensitivity and 99% specificity for HBV; 67%-80% sensitivity and 99% specificity for HCV). Most participants reported high satisfaction and acceptability with finger-prick POCTs.
CONCLUSION: POCTs for syphilis, HBV, and HCV showed high diagnostic performance among high-risk Thai AYA. Finger-prick-based POCTs demonstrated comparable accuracy and high acceptability, supporting their use in community-based STI screening.
METHODS: A cross-sectional diagnostic study was conducted among AYA aged 15-30 years with sexual risk behaviors attending a community sexual health clinic in Chiang Mai, Thailand. Several POCTs were evaluated for syphilis, HBV, and HCV using finger-prick capillary whole blood and venipuncture-derived plasma. Diagnostic performance was assessed against confirmatory reference assays. Participant satisfaction and acceptability of finger-prick-based POCTs were evaluated using a self-administered questionnaire.
RESULTS: Three hundred fifty high-risk Thai AYA (median age 23 years, 92% male, 71% self-identified as homosexual) were enrolled. Overall, 64% inconsistently used condoms, and 40% reported a lifetime history of STIs. The prevalence of seroactive syphilis, HBV, and HCV was 17%, 1%, and 4%, respectively. Finger-prick-based POCTs showed high diagnostic accuracy (92%-100% sensitivity and 90%-93% specificity for syphilis; 75% sensitivity and 99% specificity for HBV; 80% sensitivity and 99% specificity for HCV), comparable to venipuncture-based POCTs (87%-100% sensitivity and 92%-94% specificity for syphilis; 75% sensitivity and 99% specificity for HBV; 67%-80% sensitivity and 99% specificity for HCV). Most participants reported high satisfaction and acceptability with finger-prick POCTs.
CONCLUSION: POCTs for syphilis, HBV, and HCV showed high diagnostic performance among high-risk Thai AYA. Finger-prick-based POCTs demonstrated comparable accuracy and high acceptability, supporting their use in community-based STI screening.