Journal of surgical oncology · 2026
Immunotherapy in the Treatment of Soft Tissue Sarcoma Since SARC028: An NCDB Analysis.
СтатьяНазвание и аннотация: Перевод в очереди
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Dumont Galileo S, Gratny Hanna L, Keeter Carson, Wilky Breelyn A, Lanning Ryan, Donaldson Nathan J, Thorpe Steven W
Аннотация
BACKGROUND: The publication of SARC028 in late 2017 revolutionized soft tissue sarcoma (STS) treatment by demonstrating promising response to anti-PD1 immunotherapy in undifferentiated pleomorphic sarcoma (UPS) and dedifferentiated liposarcoma (DDLPS). Data on immunotherapy efficacy and outcomes in larger cohorts and with longer follow-up remain limited.
METHODS: 31 672 cases of UPS, DDLPS, alveolar soft part sarcoma, and myxofibrosarcoma were extracted from the NCDB. Factors associated with the use of immunotherapy were evaluated using logistic regression, and survival analysis was performed with Kaplan-Meier curves and Cox proportional hazards models.
RESULTS: Patients diagnosed with STS after 2017 were 3.67 times more likely to receive immunotherapy. Immunotherapy was associated with an approximately 20% reduction in mortality in stage IV STS, which was driven by cases of UPS. This survival benefit was observed in male, but not female, patients. There was no survival benefit in stage III STS.
DISCUSSION: These data are consistent with a survival benefit with immunotherapy in stage IV STS, predominantly in UPS, supporting the findings of SARC028. Benefit in stage III STS was not observed, limiting concordance with later trials like SARC032. Further prospective data on long-term outcomes and immunotherapy efficacy according to histology and sex are needed.
METHODS: 31 672 cases of UPS, DDLPS, alveolar soft part sarcoma, and myxofibrosarcoma were extracted from the NCDB. Factors associated with the use of immunotherapy were evaluated using logistic regression, and survival analysis was performed with Kaplan-Meier curves and Cox proportional hazards models.
RESULTS: Patients diagnosed with STS after 2017 were 3.67 times more likely to receive immunotherapy. Immunotherapy was associated with an approximately 20% reduction in mortality in stage IV STS, which was driven by cases of UPS. This survival benefit was observed in male, but not female, patients. There was no survival benefit in stage III STS.
DISCUSSION: These data are consistent with a survival benefit with immunotherapy in stage IV STS, predominantly in UPS, supporting the findings of SARC028. Benefit in stage III STS was not observed, limiting concordance with later trials like SARC032. Further prospective data on long-term outcomes and immunotherapy efficacy according to histology and sex are needed.