Evaluation of the Greenness of Analytical Methods for the Analysis of Tenoxicam in a Pharmaceutical Matrix.

Tenoxicam is a non-steroidal anti-inflammatory drug. Official compendia report Tenoxicam analysis by titration, while the literature reports analyses by High Performance Liquid Chromatography and Ultraviolet- Visible Spectrophotometry. Each method has its own characteristics, as do each active ingredient, and the analysis objective is also important, as is the matrix in which it is used. The combination of these factors and analytical awareness can result in a harmful, time-consuming, and costly process or a green, fast, and economical one. This work aims to evaluate the greenness of analytical methods for the analysis of Tenoxicam in a pharmaceutical matrix, using the National Environmental Methods Index, Eco-Scale Assessment, Green Analytical Procedure Index, and Blue Applicability Grade Index. The articles and monographs were selected from 2016 to 2025 from the main databases PubMed and ScienceDirect, as well as the British Pharmacopoeia. An overview of the analytical methods of the last 10 years for quantitative evaluation of Tenoxicam in pharmaceutical matrices showed that High Performance Liquid Chromatography is the most used method, methanol is the most used solvent, approximately 70% of the analyzes use toxic, hazardous and bioaccumulative reagents, average Eco-Scale Assessment of 82%, predominantly yellow Green Analytical Procedure Index and average Blue Applicability Grade Index of 66.7. There is still room to develop more environmentally friendly analytical conditions, and the combined use of green tools can guide choices and decision- making.