Amniotic fluid creatinine and uric acid levels in high risk pregnancy.

Comparison of two methods of creatinine and uric acid assay in amniotic fluid showed that the two-point-reaction rate measurement of creatinine and the enzymatic assay of uric acid give more reliable results than the methods used previously. At the end of pregnancy, increased creatinine and uric acid levels were found. In cases of blood group incompatibility the values were mostly in the normal range, while in diabetic or toxaemic mothers higher, normal and lower values were equally found. It has been concluded that a single investigation does not suffice for the estimation of fetal maturity. Only repeated tests showing an increase in the creatinine and uric acid levels offer reliable information.