This study registered rates of specific treatment options for mental disorders as well as their long-term outcome.
MATERIAL AND
METHODS
The history of mental disorders was used as a proxy for diagnosis. The data came from the COMET-G study (40 countries; 54,826 subjects, 64.73 % females, 35.45±13.51 years old). The analysis included descriptive statistics, Risk Ratios, t-tests, and ANCOVA's.
RESULTS
24.14 % reported a history of any mental disorder (depression >12 %, non-affective psychosis and Bipolar disorder 1 % each, >20 % self-injury, >10 % had attempted suicide, 7.17 % illegal substance abuse). Most patients were not under any kind of treatment (59.44 %) and most were not receiving treatment as recommended (e.g. 90 % of Bipolar and 2/3 of psychotic patients). No treatment at all and psychotherapy as monotherapy were consistently related to poorer outcomes. In anxiety or depression, only antidepressant monotherapy and benzodiazepines, in Bipolar disorder only antipsychotic monotherapy in males and antidepressant monotherapy in females and in non-affective psychosis antipsychotics and psychotherapy in females only, were related to good outcomes. No treatment modality was related to a good outcome in those with a history of self-harm, suicidal attempts, or illegal substance use. Only depression and treatment with antidepressants were related to metabolic syndrome.
DISCUSSION: In the community, the overwhelming majority of mental patients do not receive appropriate treatment or, even worse, no treatment at all. The outcome is unfavourable for the majority and only a few selective treatment options seem to make a difference.
Для цитирования: Fountoulakis Konstantinos N, Karakatsoulis Gregory, Abraham Seri, Adorjan Kristina, Ahmed Helal Uddin, Alarcón Renato D, Arai Kiyomi, Auwal Sani Salihu, Berk Michael, Levaj Sarah, Bobes Julio, Bobes-Bascaran Teresa, Bourgin-Duchesnay Julie, Bredicean Cristina Ana, Bukelskis Laurynas, Burkadze Akaki, Abud Indira Indiana Cabrera, Castilla-Puentes Ruby, Cetkovich Marcelo, Colon-Rivera Hector, Corral Ricardo, Cortez-Vergara Carla, Crepin Piirika, De Berardis Domenico, Delgado Sergio Zamora, De Lucena David, De Sousa Avinash, Stefano Ramona Di, Dodd Seetal, Elek Livia Priyanka, Elissa Anna, Erdelyi-Hamza Berta, Erzin Gamze, Etchevers Martin J, Falkai Peter, Farcas Adriana, Fedotov Ilya, Filatova Viktoriia, Fountoulakis Nikolaos K, Frankova Iryna, Franza Francesco, Frias Pedro, Galako Tatiana, Garay Cristian J, Garcia-Álvarez Leticia, García-Portilla Maria Paz, Gonda Xenia, Gondek Tomasz M, González Daniela Morera, Gould Hilary, Grandinetti Paolo, Grau Arturo, Groudeva Violeta, Hagin Michal, Harada Takayuki, Hasan Tasdik M, Razali Salmi, Hilbig Jan, Hossain Sahadat, Iakimova Rossitza, Ibrahim Mona, Iftene Felicia, Ignatenko Yulia, Irarrazaval Matias, Ismail Zaliha, Ismayilova Jamila, Jakobs Asaf, Jakovljević Miro, Jakšić Nenad, Javed Afzal, Kafali Helin Yilmaz, Karia Sagar, Kazakova Olga, Khalifa Doaa, Khaustova Olena, Koh Steve, Kopishinskaia Svetlana, Kosenko Korneliia, Vadon Nikolett Beata, Lalljee Alisha, Liewig Justine, Majid Abdul, Malashonkova Evgeniia, Malik Khamelia, Malik Najma Iqbal, Mammadzada Gulay, Mandalia Bilvesh, Marazziti Donatella, Marčinko Darko, Martinez Stephanie, Matiekus Eimantas, Mejia Gabriela, Memon Roha Saeed, Martínez Xarah Elenne Meza, Mickevičiūtė Dalia, Milev Roumen, Mohammed Muftau, Molina-López Alejandro, Morozov Petr, Muhammad Nuru Suleiman, Mustač Filip, Naor Mika S, Nassieb Amira, Navickas Alvydas, Okasha Tarek, Pandova Milena, Panfil Anca-Livia, Panteleeva Liliya, Papava Ion, Pavlichenko Alexey, Pejuskovic Bojana, da Costa Mariana Pinto, Popkov Mikhail, Popovic Dina, Raduan Nor Jannah Nasution, Ramírez Francisca Vargas, Rancans Elmars, Hashim Nurul Azreen, Rebok Federico, Rewekant Anna, Flores Elena Ninoska Reyes, Rivera-Encinas María Teresa, Saiz Pilar, de Carmona Manuel Sánchez, Martínez David Saucedo, Saw Jo Anne, Saygili Görkem, Schneidereit Patricia, Shah Bhumika, Shirasaka Tomohiro, Silagadze Ketevan, Sitanggang Satti, Skugarevsky Oleg, Spikina Anna, Mahalingappa Sridevi Sira, Stoyanova Maria, Szczegielniak Anna, Tamasan Simona Claudia, Tavormina Giuseppe, Tavormina Maurilio Giuseppe Maria, Tohen Mauricio, Tsapakis Eva Maria, Tukhvatullina Dina, Ullah Irfan, Vaidya Ratnaraj, Vega-Dienstmaier Johann M, Vrublevska Jelena, Vukovic Olivera, Vysotska Olga, Widiasih Natalia, Yashikhina Anna, Smirnova Daria. Treatment and long-term outcome of mental disorders: The grim picture from a quasi-epidemiological investigation in 54,826 subjects from 40 countries.. Psychiatry research. 2025. DOI: 10.1016/j.psychres.2025.116459.
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