Seropositivity of HBV, HCV, HIV and Syphilis among Blood Donors in Mymensingh Medical College Hospital, Bangladesh.

Transfusion-transmissible infections (TTIs) like hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV) and syphilis pose significant public health challenges, particularly in developing nations. Blood transfusions can pose a significant risk for these infections if proper screening procedures are not followed. This study aims to determine the prevalence and trends of TTIs among blood donors at Mymensingh Medical College Hospital, Bangladesh. This retrospective and cross-sectional analysis was conducted on donor records from January 2023 to December 2024. Donor samples were screened for HBV, HCV, HIV and syphilis using Immunochromatography (ICT) methods. Demographic data, including age, sex and blood group, were also analyzed, along with monthly and yearly trends. Out of 116,689 donors, 669 (0.57%) were sero-positive for at least one infection. HBV was the most prevalent (0.49%), followed by syphilis (0.07%), HCV (0.02%) and HIV (0.01%). Most sero-positive donors were male (87.9%) and within the 26-35 years age group (69.6%). Blood group O had the highest proportion (47.4%) of sero-positive cases. HIV and syphilis prevalence increased slightly in 2024 compared to 2023. The highest monthly TTI cases recorded in the month of June. Although the overall TTI prevalence among blood donors was relatively low, HBV remains a significant concern. Continuous screening, awareness campaigns and improved public health interventions are necessary to reduce the risk of TTIs and ensure safe blood transfusion practices.