Treatment with botulinum toxin type B for upper-limb spasticity.

OBJECTIVE

To determine if botulinum toxin type B (MyoBloc) decreases spasticity.

DESIGN

Investigator-initiated trial, open-label, single-treatment session.

SETTING

Single site.

PARTICIPANTS

Ten patients with stable upper-limb spasticity and an Ashworth Scale score of 2 or higher at the elbow, wrist, and fingers.

INTERVENTIONS: Total dose of 10,000U of botulinum toxin type B injected into 5 major muscles.

MAIN OUTCOME MEASURES: The Ashworth Scale, goniometry, and functional assessments were performed at injection and weeks 4, 8, and 12. The principal investigator (PI) global assessment of change (GAC) and the patient GAC were done at weeks 4, 8, and 12 postinjection. The safety of the procedure was measured by adverse events and vital signs.

RESULTS

Improvements in Ashworth Scale scores were observed at weeks 4, 8, and 12 postinjection. At week 4, the mean changes (in Ashworth score) were elbow, -1.0 (P=.016); wrist, -1.7 (P=.004); finger, -1.35 (P=.02); at week 8: elbow, -.83 (P=.016); wrist, -1.00 (P=.016); finger, -.94 (P=.08); and at week 12: elbow, -.61 (P=.07); wrist, -1.00 (P=.016); and finger, -.89 (P=.10). The PI GAC improved at all visits. Nine of the 10 subjects reported dry mouth at week 4, with resolution by week 12. No changes were seen on the functional measures.

CONCLUSIONS

Botulinum toxin type B may be useful in treatment of spasticity.