BMJ open · 2025
Three infections, one fight: an implementation study to map needle prevalence and evaluate HIV, syphilis and hepatitis C prevention interventions in Regina, Saskatchewan - a protocol.
СтатьяНазвание и аннотация: Перевод в очереди
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Eaton Andrew D, Rowe Megan W, Varghese Shiny Mary, House Heather, Pang Nelson, Kwan Sandra, Ford Pam, Reddy Vidya Dhar, Acoose Tashia, Littleford Jason, Lang Kelly, Foreman Erin S, Sasakamoose Jolee, Pandey Mamata, Medeiros Priscilla, Loutfy Mona R, Grace Daniel, Brennan David J, Zhao Kedi, Shuper Paul A, Ibáñez-Carrasco Francisco
Аннотация
INTRODUCTION: Saskatchewan is facing a public health crisis driven by high rates of HIV, syphilis and hepatitis C virus (HCV) infections, particularly among people who use drugs. Injection drug use is a major contributor to these syndemic infections, exacerbated by structural barriers such as stigma, poverty and limited culturally safe healthcare. Innovative, community-informed approaches are urgently needed to improve prevention, testing and linkage to care.
METHODS AND ANALYSIS: This study will implement a rapid assessment and response system in Regina, Saskatchewan, Canada, integrating geospatial mapping of community needle prevalence with pop-up interventions. Needle hotspot maps will be used to guide the deployment of community-based pop-up events offering point-of-care testing for HIV, syphilis and HCV, alongside education on pre-exposure prophylaxis (PrEP) and postexposure prophylaxis (PEP). A convergent participatory mixed-methods design will be used to evaluate feasibility, acceptability and effectiveness, guided by the Reach, Effectiveness, Adoption, Implementation and Maintenance framework. Quantitative data will assess changes in knowledge of PrEP and PEP, satisfaction with the intervention and report new diagnoses and participant demographics descriptively. A qualitative substudy will include 30 participants and will explore experiences with the intervention, barriers to care and perceptions of service delivery.
ETHICS AND DISSEMINATION: Ethical approval has been obtained from the research ethics board of the Saskatchewan Health Authority (#24-91). Findings will be disseminated through peer-reviewed publications, conference presentations and community reporting. This study may provide a model of community-based geospatial testing and education that could be scaled up and adapted elsewhere.
REGISTRATION: Open Science Framework https://doi.org/10.17605/OSF.IO/HVK3B.
METHODS AND ANALYSIS: This study will implement a rapid assessment and response system in Regina, Saskatchewan, Canada, integrating geospatial mapping of community needle prevalence with pop-up interventions. Needle hotspot maps will be used to guide the deployment of community-based pop-up events offering point-of-care testing for HIV, syphilis and HCV, alongside education on pre-exposure prophylaxis (PrEP) and postexposure prophylaxis (PEP). A convergent participatory mixed-methods design will be used to evaluate feasibility, acceptability and effectiveness, guided by the Reach, Effectiveness, Adoption, Implementation and Maintenance framework. Quantitative data will assess changes in knowledge of PrEP and PEP, satisfaction with the intervention and report new diagnoses and participant demographics descriptively. A qualitative substudy will include 30 participants and will explore experiences with the intervention, barriers to care and perceptions of service delivery.
ETHICS AND DISSEMINATION: Ethical approval has been obtained from the research ethics board of the Saskatchewan Health Authority (#24-91). Findings will be disseminated through peer-reviewed publications, conference presentations and community reporting. This study may provide a model of community-based geospatial testing and education that could be scaled up and adapted elsewhere.
REGISTRATION: Open Science Framework https://doi.org/10.17605/OSF.IO/HVK3B.