Alzheimer's & dementia (Amsterdam, Netherlands) · 2026
Arterial stiffness and risk of dementia in late life: The ARIC neurocognitive study.
СтатьяНазвание и аннотация: Перевод в очереди
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Barbee Jenna, Pike James Russell, Wei Jingkai, Tanaka Hirofumi, Knopman David S, Kucharska-Newton Anna, Sharrett A Richey, Hughes Timothy M, Matsushita Kunihiro, Mosley Thomas H, Meyer Michelle L, Palta Priya
Аннотация
INTRODUCTION: Associations of arterial stiffness, measured through pulse wave velocity (PWV), with incident dementia may be driven by age-related structural changes to the arterial wall or by elevated blood pressure.
METHODS: Dementia-free White or Black participants in the community-based Atherosclerosis Risk in Communities (ARIC) cohort study with measures of PWV were examined. The associations of carotid-femoral PWV (cfPWV) and total, structural, and load-dependent PWV with dementia were estimated using Poisson regression models and Cox proportional hazards models. Dementia cases were defined by physician-adjudicated review, telephone interviews, hospitalization records, and death certificates.
RESULTS: Of 4818 participants included in the study population (mean age: 75 years; 41% male, 21% Black), 1067 (22%) developed dementia over a median follow-up of 9.0 years. Higher cfPWV, total PWV, structural PWV, and load-dependent PWV were associated with greater dementia risk.
DISCUSSION: Both structural and pressure-related arterial stiffness mechanisms may underlie the link between PWV and dementia.
METHODS: Dementia-free White or Black participants in the community-based Atherosclerosis Risk in Communities (ARIC) cohort study with measures of PWV were examined. The associations of carotid-femoral PWV (cfPWV) and total, structural, and load-dependent PWV with dementia were estimated using Poisson regression models and Cox proportional hazards models. Dementia cases were defined by physician-adjudicated review, telephone interviews, hospitalization records, and death certificates.
RESULTS: Of 4818 participants included in the study population (mean age: 75 years; 41% male, 21% Black), 1067 (22%) developed dementia over a median follow-up of 9.0 years. Higher cfPWV, total PWV, structural PWV, and load-dependent PWV were associated with greater dementia risk.
DISCUSSION: Both structural and pressure-related arterial stiffness mechanisms may underlie the link between PWV and dementia.