The intermediary role of resilience and psychological distress in the relationship between functional limitations and well-being among racial/ethnic minority persons with multiple sclerosis.

Racial/ethnic minorities with multiple sclerosis (MS) may face additional compounding stressors including access to care and cultural values. This study aimed to investigate the indirect role of resilience and psychological distress in the relationship between functional limitations and well-being in a sample of 224 racial/ethnic minorities with MS. Serial mediation analysis was conducted to examine the indirect effect of functional limitations on well-being through resilience and psychological distress. Our findings suggested that functional limitations were negatively associated with resilience and well-being, and were positively associated with psychological distress. Resilience was negatively associated with psychological distress and positively associated with well-being. Our serial mediation results provided preliminary support for resilience and psychological distress as partial mediators between the relationship of functional limitations and well-being. These findings may contribute to an understanding of the roles of resilience and psychological health in the relationship between functional limitations and well-being, which may be critical in addressing disparities in MS care and support.