Journal of nephrology · 2026
Are children with isolated renal ectopia at increased risk of hypertension? Evidence from an observational study.
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Sahin Gorkem, Cagli Piskin Cagla, Orhan Ok Zahide, Sasmaz Nurdag Nimet, Atmis Bahriye, K Bayazit Aysun
Аннотация
BACKGROUND: This study aimed to evaluate blood pressure profiles in children with isolated renal ectopia by using ambulatory blood pressure monitoring (ABPM) to determine the prevalence and patterns of hypertension, and to explore the relationships between ectopy subtype and kidney function.
METHODS: Clinical and ABPM data from 24 children with isolated renal ectopia followed between January 2024 and January 2025 at Çukurova University Department of Pediatric Nephrology were evaluated. Type of ectopia, presence of decreased renal parenchymal uptake on dimercaptosuccinic acid (DMSA) scintigraphy, estimated glomerular filtration rate (eGFR) and presence of end organ damage were also assessed. On the day of ABPM, standard deviation scores (SDS) were recorded for anthropometric measurements and office and 24-hour BP values.
RESULTS: Of 24 patients (66.7% male), 75% had simple ectopia and 25% had crossed-fused ectopia. Mean age was 11.3 ± 3.7 years. Masked hypertension was identified in 45.8%. eGFR negatively correlated with 24-hour systolic BP SDS (r = -0.456, P = .02), nighttime diastolic BP SDS (r = -0.417, P = .04), and nighttime systolic BP SDS (r = -0.487, P = .01). Decreased parenchymal uptake was present in 50% of patients and was associated with lower height SDS (P = .03), higher nighttime systolic BP SDS (P = .01) and increased frequency of systolic non-dipping (91.7% vs. 45.5%; P = .02). The crossed-fused renal ectopia group had a higher prevalence of vesicoureteral reflux (P = .009) and lower eGFR (P = .01).
CONCLUSION: Children with isolated renal ectopia show a high prevalence of ABPM abnormalities, particularly masked hypertension and altered nocturnal blood pressure patterns. Regular monitoring of growth, kidney function, and blood pressure is essential to detect both early and late complications.
METHODS: Clinical and ABPM data from 24 children with isolated renal ectopia followed between January 2024 and January 2025 at Çukurova University Department of Pediatric Nephrology were evaluated. Type of ectopia, presence of decreased renal parenchymal uptake on dimercaptosuccinic acid (DMSA) scintigraphy, estimated glomerular filtration rate (eGFR) and presence of end organ damage were also assessed. On the day of ABPM, standard deviation scores (SDS) were recorded for anthropometric measurements and office and 24-hour BP values.
RESULTS: Of 24 patients (66.7% male), 75% had simple ectopia and 25% had crossed-fused ectopia. Mean age was 11.3 ± 3.7 years. Masked hypertension was identified in 45.8%. eGFR negatively correlated with 24-hour systolic BP SDS (r = -0.456, P = .02), nighttime diastolic BP SDS (r = -0.417, P = .04), and nighttime systolic BP SDS (r = -0.487, P = .01). Decreased parenchymal uptake was present in 50% of patients and was associated with lower height SDS (P = .03), higher nighttime systolic BP SDS (P = .01) and increased frequency of systolic non-dipping (91.7% vs. 45.5%; P = .02). The crossed-fused renal ectopia group had a higher prevalence of vesicoureteral reflux (P = .009) and lower eGFR (P = .01).
CONCLUSION: Children with isolated renal ectopia show a high prevalence of ABPM abnormalities, particularly masked hypertension and altered nocturnal blood pressure patterns. Regular monitoring of growth, kidney function, and blood pressure is essential to detect both early and late complications.