Exploiting Solanum tuberosum L. (Vitelotte Noire Cultivar) Peel as a Sustainable Antioxidant Source for Nutraceutical Applications.

The valorization of agri-food by-products aligns with circular economy principles and offers sustainable sources of bioactive compounds. This study investigated the peels of the purple-fleshed Solanum tuberosum L. cv. Vitelotte Noire (VN), cultivated in Sardinia, as a potential resource for nutraceutical antioxidants. Extracts were obtained using solvents of different polarities (water, 80% and 96% ethanol) and characterized. Phytochemical screening revealed high concentrations of total phenolics, flavonoids, and anthocyanins, with the 96% ethanolic extract showing superior anthocyanin content. Antioxidant capacity, assessed via ORAC-PYR, TEAC-ABTS, and DPPH assays, was highest in the alcoholic extracts. Furthermore, all extracts showed protective effects in an in vitro model of AAPH-induced oxidative DNA damage, as indicated by the preservation of plasmid supercoiling. Untargeted LC-QTOF-MS analysis detailed a rich metabolomic profile, including organic acids, amino acids, and vitamins. The findings confirm VN peel as a potent, sustainable source of antioxidants, supporting its valorization for developing high-added-value nutraceutical and functional food ingredients, while reducing waste disposal costs and environmental impact.