Cardiovascular revascularization medicine : including molecular interventions · 2026
Acute and late relocation of minimal lumen area after implantation of a magnesium-based bioresorbable scaffold.
СтатьяНазвание и аннотация: Перевод в очереди
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Grønbech Julie, Hansen Kirstine Nørregaard, Trøan Jens, Christensen Christian Alexander, Hougaard Mikkel, Jensen Lisette Okkels
Аннотация
BACKGROUND: Minimal lumen area (MLA) relocation occurs when the smallest cross-sectional area in a treated coronary artery segment shifts location after percutaneous coronary intervention (PCI).
AIM: To investigate acute and late MLA relocation after Magnesium based bioresorbable scaffold (MgBRS) implantation, compare lumen, scaffold, plaque, and vessel dimensions in patients with and without MLA shift using optical coherence tomography (OCT) and intravascular ultrasound (IVUS), while also identifying predictors of MLA relocation.
METHODS: In a substudy of the Optimal Pre-dilatation Treatment before Implantation of a Magmaris bioresorbable scaffold in coronary artery Stenosis (OPTIMIS) trial, 74 patients with stable angina undergoing PCI with MgBRS were evaluated with serial OCT and IVUS imaging. MLA was assessed pre-procedure, post-procedure, and at 6-month follow-up. Relocation was defined as axial MLA shift and classified as acute (pre- to post-procedure) or late (post-procedure to follow-up).
RESULTS: Acute MLA relocation occurred in 46 (62.2%) patients, of whom 26 (56.5%) also experienced late relocation. Patients with acute relocation had larger post-procedural lumen volumes (183.9 mm3 ± 48.0 vs 137.1 mm3 ± 51.2, p < 0.001) and scaffold volumes (177.2 ± 46.4 vs 133.8 ± 41.6, p < 0.001) compared to patients without acute MLA relocation. Larger lumen and scaffold volumes persisted at follow-up. MLA was more often located at the scaffold edge in patients with acute relocation compared to patients without acute MLA relocation (23 (50.0%) vs 1 (3.6%), p < 0.001). At 6-month follow-up, the MLA was located at the scaffold edge in 30.4% of patients with late relocation versus 46.4% without late relocation (p = 0.15). No independent predictors of acute nor late MLA relocation were found.
CONCLUSION: Acute and late MLA relocation were common after MgBRS implantation. In patients with acute relocation, MLA was more often located at the scaffold edge at post-procedure compared to patients without acute relocation.
AIM: To investigate acute and late MLA relocation after Magnesium based bioresorbable scaffold (MgBRS) implantation, compare lumen, scaffold, plaque, and vessel dimensions in patients with and without MLA shift using optical coherence tomography (OCT) and intravascular ultrasound (IVUS), while also identifying predictors of MLA relocation.
METHODS: In a substudy of the Optimal Pre-dilatation Treatment before Implantation of a Magmaris bioresorbable scaffold in coronary artery Stenosis (OPTIMIS) trial, 74 patients with stable angina undergoing PCI with MgBRS were evaluated with serial OCT and IVUS imaging. MLA was assessed pre-procedure, post-procedure, and at 6-month follow-up. Relocation was defined as axial MLA shift and classified as acute (pre- to post-procedure) or late (post-procedure to follow-up).
RESULTS: Acute MLA relocation occurred in 46 (62.2%) patients, of whom 26 (56.5%) also experienced late relocation. Patients with acute relocation had larger post-procedural lumen volumes (183.9 mm3 ± 48.0 vs 137.1 mm3 ± 51.2, p < 0.001) and scaffold volumes (177.2 ± 46.4 vs 133.8 ± 41.6, p < 0.001) compared to patients without acute MLA relocation. Larger lumen and scaffold volumes persisted at follow-up. MLA was more often located at the scaffold edge in patients with acute relocation compared to patients without acute MLA relocation (23 (50.0%) vs 1 (3.6%), p < 0.001). At 6-month follow-up, the MLA was located at the scaffold edge in 30.4% of patients with late relocation versus 46.4% without late relocation (p = 0.15). No independent predictors of acute nor late MLA relocation were found.
CONCLUSION: Acute and late MLA relocation were common after MgBRS implantation. In patients with acute relocation, MLA was more often located at the scaffold edge at post-procedure compared to patients without acute relocation.