TNF-α, An Inflammatory Path, Rerouted Through Alternate Medicinal Channels.

INTRODUCTION

This study emphasizes the efficacy of triphala as a therapeutic agent over inflammatory condition in hydrogen sulfide (H2 S) mediated inflammatory path in the presence of titanium (Ti) discs.

MATERIALS AND METHOD: In the presence of triphala extracts, lipopolysaccharidetreated macrophages showed reduction in production of inflammatory mediators and intercellular free radicals (ROS) and downregulation of mRNA in TNF.

RESULTS

Thus in the presence of propargylglycine, reduction of TNFα by triphala in the H2 S inhibited group showed that the mechanism of action of triphala can be through the H2 S pathway.