JACC. Case reports · 2025
Loperamide-Induced Ventricular Arrhythmia and Seizures.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Lateef Azalfa, Vardar Ufuk, Sanclemente Drew, Lee Bridget, Pasupula Deepak, Tseng Andrew S, van Niekerk Christoffel J
Аннотация
BACKGROUND: Loperamide-induced cardiotoxicity can occur when taken at high doses.
CASE SUMMARY: A 42-year-old man presented with polymorphic ventricular tachycardia after taking 100 to 200 mg of loperamide daily to self-treat opioid withdrawal. The presenting electrocardiogram showed a wide complex rhythm which spontaneously converted to sinus rhythm with a prolonged QT interval. Implantable cardiac-defibrillator therapies treated polymorphic ventricular tachycardia and ventricular fibrillation. Loperamide was discontinued, and he was treated for opioid use disorder.
DISCUSSION: Loperamide can cause cardiotoxic manifestations such as acquired long QT syndrome with associated ventricular arrhythmias and neurologic manifestations such as seizures.
TAKE-HOME MESSAGE: Although loperamide is an over-the-counter medication, life threatening cardiotoxicity and neurotoxicity can occur with high doses.
CASE SUMMARY: A 42-year-old man presented with polymorphic ventricular tachycardia after taking 100 to 200 mg of loperamide daily to self-treat opioid withdrawal. The presenting electrocardiogram showed a wide complex rhythm which spontaneously converted to sinus rhythm with a prolonged QT interval. Implantable cardiac-defibrillator therapies treated polymorphic ventricular tachycardia and ventricular fibrillation. Loperamide was discontinued, and he was treated for opioid use disorder.
DISCUSSION: Loperamide can cause cardiotoxic manifestations such as acquired long QT syndrome with associated ventricular arrhythmias and neurologic manifestations such as seizures.
TAKE-HOME MESSAGE: Although loperamide is an over-the-counter medication, life threatening cardiotoxicity and neurotoxicity can occur with high doses.